Causes of osteomalacia

• vitamin D deficiency
  • dietary deficiency
  • lack of ultraviolet light exposure – especially dark-skinned people who spend little time in the sun
  • malabsorption – gastrointestinal, hepatic, and pancreatic disease
• abnormal metabolism of vitamin D
  • chronic renal failure (CRF)
  • vitamin-D-dependent Rickets – 1-hydroxylase deficiency
  • anticonvulsant osteopathy
• phosphate depletion
  • X-linked (dominant) hypophosphatemia
  • Fanconi syndrome
• renal tubular acidosis