The mix of variable pathophysiology, geographic distinctiveness, inconstant clinical penetrance, and complex host-parasite interaction make for a smouldering 'Neglected Tropical Disease' affecting 12 million of the world’s poorest. Leishmania infect phagocytes, outwitting the host immune system. Caught early and trapped locally, the organism replicates within dendritic cells (dermal macrophages) causing only cutaneous disease. Another species (there are 20 that are pathogenic to … Continue reading Dum Dum Fever