Calcium-channel blockers (CCBs) inhibit voltage-gated calcium channels, responsible for excitation-contraction coupling at skeletal, smooth, and cardiac muscle end-plates and sarcoplasmic reticulum, but also for conduction of the pace-maker signal in the heart. INDICATIONS Hypertension Angina Calcium-channel blockers inhibit cellular calcium-ion influx in: Vascular smooth muscle The non-dihydropyridines, diltiazem and verapamil, reduce coronary arteriole vascular resistance … Continue reading Calcium channel blockers