The P2Y12 receptor, pivotal to platelet activation, has been targeted in the development of antithrombotics for use in ACS in particular. The direct substrate of energy metabolism, adenosine diphosphate (ADP) binds to the P2Y12 receptor. ADP is also stored in platelet granules. This ADP binding results in activation of the platelet which causes a conformational … Continue reading Antithrombotics: the P2Y12 Platelet Receptor and its role in Haemostasis