Cirrhosis – causes

Investigate the young patient with cirrhosis carefully as they may have a treatable cause:

  • alcohol
  • chronic active hepatitis
    • HBV / HCV / HDV
    • autoimmune – primary biliary cirrhosis, secondary biliary cirrhosis, primary sclerosing cholangitis (I/II)
    • drugs – nitrofurantoin, methyldopa
    • Wilson’s disease
  • haemochromatosis
  • cryptogenic (idiopathic)
  • non-alcoholic steatohepatitis – fatty liver
    • diabetes mellitus
    • toxins
  • others
    • cardiac failure
    • hepatic vein obstruction (Budd-Chiari syndrome)
    • α1-antitrypsin deficiency
    • inherited metabolic disorders

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